Best Chicken Spaghetti Casserole [VIDEO]

Catalina Castravet
By Catalina Castravet
Updated:
Published:
5 from 18 reviews

Chicken Spaghetti Casserole is a very easy and hearty dinner. Loaded with chicken, veggies, spaghetti, lots of cheddar cheese and baked in a mushroom sauce.

Casserole recipes are a favorite around here, they are easy to make and usually make enough leftovers so I don’t have to worry about cooking dinner the next day again.

I like to take the time and prep a few sometimes ahead of time and freeze them, to have dinner readily available for crazy weeknights. We often make this Cheesy Crack Chicken Casserole, White Pizza Casserole, and Chicken Hash-brown Casserole.

Image of chicken spaghetti casserole.

Best Chicken Spaghetti Casserole Recipe

This Chicken Spaghetti Casserole is such a classic dish and is always a hit with my family. It is very easy to adapt to your own taste preference because you can skip the veggies or add more. Also, you can also make this casserole with other meat. For instance, I made it a few times with spicy Italian sausage and I also tried it with leftover turkey, both versions were delicious.

The casseroles are a great option when you don’t want to cook every single night or have a very large family. They are usually easy to make, and large enough to serve to a crowd or have leftovers.

Casseroles also freeze well, which means you can make a few ahead of time and freeze for busy times. When you are ready to serve, just pop it in the oven and a stress-free homemade dinner is ready.

Chicken Spaghetti Casserole frequently asked questions:

  •  Can you make this casserole with whole wheat spaghetti: the answer is short and simple, yes, you can, and it will be delicious.
  • Are other cheeses OK to use, besides yellow cheddar cheese: yes, you can, in fact, I have tried this casserole with mozzarella cheese, and it tastes amazing. You can use any cheese that melts well, provolone and pepper jack cheese are also great options.
  • Are mushrooms necessary:  I know mushrooms divide people, some love them, some hate them. Yes, you can skip the mushrooms in this recipe or you can replace them with chopped celery, or more bell peppers.
  • Will rotisserie chicken be OK to use making this casserole: actually using rotisserie chicken is a great shortcut to make this recipe. You can also use leftover turkey. If you are tired of turkey sandwiches, making this casserole is a much tastier option.
  • Is turkey an option to use instead of chicken: yes, you can.
  • What other veggies can I use in this casserole: It is actually up to you, you can thaw a package of mixed veggies like peas, carrots, and broccoli. You can also use mushrooms, bell peppers, and even chopped zucchini. Spinach is also a great alternative if you are looking to add more greens. If you want something fancier, a cup of chopped sun-dried tomatoes in oil would work great. Combine the latest with some spinach and you have a Tuscan Chicken Spaghetti Casserole.
  • Can you prep this casserole ahead of time: yes, you can. Follow all the instructions and assemble the casserole fully. Then, cover with plastic food wrap and refrigerate for up to 2 days.

Photo of cheesy chicken spaghetti casserole.

Possible flavors variations:

  • Ranch – add one package of Ranch Dry Mix and 1 cup of Ranch salad dressing, for a delicious Ranch flavor.
  • Buffalo – add one cup of Buffalo sauce into the mix and you will have a Buffalo Chicken Spaghetti Casserole.
  • Blue Cheese – add one to two cups of blue cheese salad dressing to the mix, and also top the casserole with crumbled cheese, for a tasty Blue Cheese flavor.

What is Condensed Cream of Mushroom Soup?

Condensed soup is a canned variety of soup that is prepared with a reduced proportion of water. A liquid, like water or milk, is added to the soup when heated up. Alson, condensed soup is used often to add more flavor and creaminess in many recipes.

Condensed Cream of Mushroom Soup substitute:

Don’t worry, if you are not from the US and can’t get your hands on Condensed Cream of Mushroom Soup, or simply want a homemade, more wholesome version. You can use the below recipe to make a quick homemade version, which will make roughly about 3 cups of soup, enough to replace 2 (10 1/2 oz each) cans of condensed cream of mushroom soup.

Ingredients:

  • 4 ounces baby Bella mushrooms, finely diced
  • 6 tablespoon unsalted butter
  • 2/3 cup all-purpose flour
  • 2/3 cup whole or skim milk
  • 2/3 cup chicken broth or veggie broth
  • 1 teaspoon garlic powder
  • 1 teaspoon onion powder
  • 1 teaspoon ground thyme
  • salt and pepper to taste

Directions:

  1. First, place a medium saucepan over medium heat. Once hot, add the butter and melt it.
  2. Then, add diced mushrooms and cook stirring for 2-3 minutes.
  3. Add flour to the mushroom and butter mix, and stir well to combine and form a paste.
  4. Whisk in milk slowly until fully combined with no lumps.
  5. Next, whisk in broth, slowly again, until fully combined.
  6. Then, stir in garlic, onion powder, thyme and adjust for salt and pepper.
  7. Lastly, whisk the mixture until it starts to simmer. Let it simmer on low heat for about 2 minutes. The soup should be smooth and creamy. If it’s too dense, whisk in a little more milk or broth.
  8. When replacing the Condensed Cream of Mushroom Soup use a 1:1 ratio, so if you are using a 10 1/2 ounces can of condensed soup, you will need 1 1/3 cup of the homemade version to replace in recipes.
  9. The homemade soup can be stored in an airtight container in the refrigerator for up to 3-4 days.

Photo of chicken spaghetti casserole on a white plate.

How to freeze this chicken casserole?

To freeze, first, transfer the mixture to a buttered 9-by-13-inch freezer-to-oven baking dish. Then, cover tightly with aluminum foil. Freeze for up to 6 months. Bake, frozen and covered with foil, at 350°F, for 1 hour.

Looking for more Casserole Recipes? Check these out:

 

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5 from 18 reviews

Best Chicken Spaghetti Casserole

Chicken Spaghetti Casserole is a very easy and hearty dinner. Loaded with chicken, veggies, spaghetti, lots of cheddar cheese and baked in a mushroom sauce.

Author: Catalina Castravet Serves: 8 servings
Prep time: 20 minutes Cook time: 1 hour 10 minutes Total time: 1 hr 30 mins

Ingredients

Topping:

Instructions

Cook Chicken:

Cook Spaghetti:

Assemble:

Buttery Cracker Topping:

Baking:

Nutrition information

Calories: 703 Carbohydrates: 59 Protein: 48 Fat: 29 Saturated Fat: 15 Cholesterol: 171 Sodium: 1579 Potassium: 830 Fiber: 2 Sugar: 5 Vitamin A: 920 Vitamin C: 28.7 Calcium: 454 Iron: 3.7
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Picture of chicken spaghetti casserole.

Categories:

Casseroles Chicken Pasta

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Comments

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Denay

Oh my goodness! What a perfect mid-week meal! I'm ready to take my fork and dig right into this deliciousness. Thank you for sharing this excellent recipe for chicken spaghetti casserole!

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Shannan P

I love a good casserole! This looks like a great way to use up leftovers!

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Lori Bosworth

I love casseroles because they are so easy to make. This looks like delicious comfort food...can't wait to try it!

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Melanie Bauer

Looks so fabulous! I love everything about this, so tasty and hearty!

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Abeer

I love to have a big family dinner on weekends. This will be happening!

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Lisa Favre

My husband's favorite pasta is spaghetti so he'd love this casserole, guaranteed! I've never made anything quite like this, so it would be a nice surprise for the fam.

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Jamielyn

This looks so delicious! Perfect weeknight dinner!

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Rachel

I have tried this at friends' houses and never knew how to make it. It is comfort food at its best.

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Kathy

This recipe looks really good. I've never had anything like this before. I can't wait to try out your recipe now. I bet it will be delicious.

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Chrissie Baker

What a wonderful casserole idea. Is good food and this looks like one of the BEST!

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Cathy

Oooh I love this creamy twist on spaghetti!!

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Shannon Gurnee

I've never had Chicken Spaghetti Casserole before, but it looks and sounds like a yummy dish! I would love to try this sometime.

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Nancy at Whispered Inspirations

Mmm, this looks so good. My family loves spaghetti, this is a fun way to enjoy it. Bookmarking this, thanks!

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Sandra | A Dash of Sanity

My kids will love this for dinner any night!

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Gloria

This looks so good. I am printing it off right now. I think my grandkids would love this on our next sleepover weekend.

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Claudia Lamascolo

I love fall recipes like this one its perfect for the kids all in one pan easy and everything they like is in it

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Karyl Henry

I'm not usually a fan of leftovers, but the ones I do like are almost always a casserole! I'm loving this chicken spaghetti, and will definitely be making it soon

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Lauren Vavala

Such a delicious recipe that my whole family will love! My fiance's aunt made us traditional spaghetti casseroles when our son was born and I keep saying I'm going to make one, and this version is definitely more our style!

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Dianna

I have never tried chicken spaghetti but it looks like its going to be my new favorite dinner option.

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Denay DeGuzman

Mmmm...what a hearty, savory casserole! The perfect mid-week meal the whole family will enjoy.

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Mahy Elamin

Now this will be my favorite casserole! YUM! This looks so delicious! Is good food and this looks like one of the BEST!!

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Dan Zehr

Please give me a bit of this incredible casserole !! Love Love Love this recipe! I'm sure these tastes are amazing! So YUMMY!

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April

First of all, the images are spectacular! They make me want to crave for food immediately! And also, casseroles are the best because, I agree, they give a lot of leftovers - essential to what I need these busy days!

Reply

Thank you!

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Veena Azmanov

I love the topping. Never thought to add a crisp topping on pasta. Sounds so yum. Saving this for later.

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Catherine

What a fantastic combo and such a fun dish for the whole family. This looks so good...perfect especially for the weeknights!

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Marisa Franca

What a great weeknight meal! Quick and easy to prepare ahead of time and hearty too. I would use the rotisserie chicken -- it's cooked, already seasoned and costs just about as much to buy a whole bird. Such an adaptable recipe -- I like that. Great recipe to have on hand.

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Pavani

Wow, that casserole with spaghetti looks amazing. Love that crispy panko breadcrumbs crust. Perfect to make ahead of time.

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Cecelia

Made this last week and my boyfriend couldn't get enough! He ate the leftovers and we went to the grocery store and he insisted I pick up the ingredients again! Will be making it for him again tonight! Thank you so much for this winner! I added peas and bacon and a ranch seasoning packet as well!

Reply

Hi Cecelia, this is a favorite in our house as well. It makes me very happy that you guys enjoyed it!! Thank you for the feedback!

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Darlene Loupe

Could you use cream of chicken or cream of celery instead of the cream of mushroom soup?

Reply

yes :)

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Leza Whitley

Could you do this in a crock pot.

Reply

It would be a completely different recipe, sorry.

Reply

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